Articular manifestations and pain:
Articular manifestations are frequent and are often opening. Arthralgia and arthritis are mose often parts of the Lofgren's syndrome. Arthralgia and arthritis affect the large joints (mainly ankles, knees, wrists), symmetrically, fugitive, and migratory inflammatory pace. It is rare that the stage of chronic arthritis that change bone radiographs and synovial biopsy allows to find a sarcoidosis granuloma.
Skin manifestations and Sarcoidosis pain:
Apart from non-specific lesions such as erythema nodosum (present in 17% of cases), sarcoidosis presents a major polymorphism skin. The lesions predominate in the face and on the upper chest. All these lesions are accessible to biopsies. The specific skin lesions evolves favorably or become chronic.
Sarcoidosis pain - Eye:
An eye sarcoidosis is observed in more than 25% of cases. This is sometimes asymptomatic, justifying a systematic ophthalmological examination. The uveitis can be integrated into Heerfordt syndrome (uveitis earlier bilateral hypertrophy parotid, peripheral facial paralysis). The functional prognosis depends on the existence of a posterior uveitis which, untreated, localizes near the macula and may progress to blindness.
Sarcoidosis pain- Bones
Bone localizations were observed in 5 to 15% of cases, most often hidden and painless. Sarcoidosis is especially located in the tubular bones of the extremities (90% of cases). The fabrics are light,normal in principle. Radiologically, there are three forms: lytic form, large bubble shape circumscribed, cystic and diffusely microgeodic.
Sarcoidosis pain - Neuromuscular Impairment:
Neurological locations may be multiple, diffuse and affects the meninges, the central nervous system, the cranial nerves, the peripheral nervous system and the muscles. The infringement involves the functional and vital prognosis. Achieving meningitis is most often asymptomatic, characterized by an increase of the converting cerebrospinal fluid angiotensin enzyme. The achievement of the central nervous system (CNS) may sit in the brain, brainstem and cerebellum.
The main events are:
In fact, all central neurological signs can be observed.
Cardiac Sarcoidosis pain :
The presence of clinical signs is the witness of a diffuse and severe myocardial infiltration. It is therefore important to find this location. The circumstances of discovery and clinical signs of cardiac sarcoidosis are nonspecific. Sudden death is possible, by serious ventricular rhythm disorder or third degree atrioventricular block . Signs of congestive heart failure, most often chronic, is observed in more than a third of cases of cardiac sarcoidosis.
Achieving pericardial is usually asymptomatic. The electrocardiogram (ECG) is pathological in about 50% of cases of sarcoidosis. The conduction disorders are more common, as well as ventricular arrhythmias. Their presence may lead to the prescription of a holter ECG over 24 hours and an electrophysiological study of it's bundle.
Impairment of exocrine glands:
The parotidomegalie, often bilateral, may be very large, but usually is not painful and is covered with normal skin. It can, for compression, lead to peripheral facial paralysis. Impairment of salivary and lacrimal glands accessory is common and should be sought by a sugar test and a Schirmer Rose Bengal test.
Renal Impairment and Sarcoidosis pain:
The specific renal disease, unrelated to a possible hypercalcaemia with renal failure, is observed in less than 1% of cases. The renal prognosis is good and responds to high doses of corticosteroids. The other locations are quite exceptional.